Publications


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Dixit, S.S., Jadot, M., Sohar, I., Sleat, D.E., Stock, A.M., and Lobel, P. (2011)
Loss of Niemann-Pick C1 or C2 protein results in similar biochemical changes suggesting that these proteins function in a common lysosomal pathway.
PLoS One 6: e23677

Barbieri, C.M., Mack, T.R., Robinson, V.L., Miller, M.T., and Stock, A.M. (2010)
Regulation of response regulator autophosphorylation through interdomain contacts.
J. Biol. Chem. 285: 32325-32335

Gao, R., and Stock, A.M. (2010)
Molecular strategies for phosphorylation-mediated regulation of response regulator activity.
Curr. Opin. Microbiol. 13: 160-167

Gao, R., and Stock, A.M. (2009)
Catalytically incompetent by design.
Structure 17: 1038-1040

Gao, R., and Stock, A.M. (2009)
Biological insights from structures of two-component proteins.
Annu. Rev. Microbiol. 63: 133-154

Mack, T.R., Gao, R., and Stock, A.M. (2009)
Probing the roles of the two different dimers mediated by the receiver domain of the response regulator PhoB.
J. Mol. Biol. 389: 349-364

Guhaniyogi, J., Sohar, I., Das, K., Stock, A.M., and Lobel, P. (2008)
Crystal structure and autoactivation pathway of the precursor form of human tripeptidyl-peptidase 1, the enzyme deficient in late infantile ceroid lipofuscinosis.
J. Biol. Chem. 284: 3985-3997

Gao, R., Tao, Y., and Stock, A.M. (2008)
System-level mapping of Escherichia coli response regulator dimerization with FRET hybrids.
Mol. Microbiol. 69: 1358- 1372

Sidote, D.J., Barbieri, C.M., Wu, T. and Stock, A.M. (2008)
Structure of the Staphylococcus aureus AgrA LytTR domain bound to DNA reveals a beta fold with an unusual mode of binding.
Structure 16: 727-735

Barbieri, C.M. and Stock, A.M. (2008)
Universally applicable methods for both in vitro and in vivo monitoring of response regulator aspartate phosphorylation using Phos-tag-based reagents.
Anal. Biochem. 376: 73-82

Guhaniyogi, J., Wu, T., Patel, S.S. and Stock, A.M. (2008)
Interaction of CheY with the C-terminal peptide of CheZ.
J. Bacteriol. 190: 1419-1428

Dixit, S.S., Sleat, D.E., Stock, A.M. and Lobel, P. (2007)
Do mammalian NPC1 and NPC2 play a role in intestinal cholesterol absorption?
Biochem. J. 408: 1-5

Stock, A.M. (2007)
Diguanylate cyclase activation: It takes two.
Structure 15: 887-888

Xu, S., Benoff, B., Liou, H.-L., Lobel, P. and Stock, A.M. (2007)
Structural basis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease.
J. Biol. Chem. 282: 23525-23531

Bachhawat, P. and Stock, A.M. (2007)
Crystal structures of the receiver domain of response regulator PhoP from Escherichia coli in the absence and presence of the phosphoryl analog beryllofluoride.
J. Bacteriol. 189: 5987-5995

Friedland, N., Mack, T.R., Yu, M., Hung, L.-W., Terwilliger, T.C., Waldo, G.S. and Stock, A.M. (2007)
Domain orientation in the inactive response regulator Mycobacterium tuberculosis MtrA provides a barrier to activation.
Biochemistry 46: 6733-6743

Gao, R., Mack, T.R. and Stock, A.M. (2007)
Bacterial response regulators: versatile regulatory strategies from common domains.
Trends Biochem. Sci. 32: 225-234

Perez, E. and Stock, A.M. (2007)
Characterization of the Thermotoga maritima chemotaxis methylation system that lacks pentapeptide-dependent methyltransferase CheR:MCP tethering.
Mol. Microbiol. 63: 363-378

Stock, A.M. and Guhaniyogi, J. (2006)
A new perspective on response regulator activation.
J. Bacteriol. 188: 7328-7330

Stock, A.M. (2006)
Transmembrane signaling by asymmetry.
Nat. Struct. Mol. Biol. 13: 861-862

Liou, H.L., Dixit, S.S., Xu, S., Tint, G.S., Stock, A.M. and Lobel, P. (2006)
NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols.
J. Biol. Chem. 281: 36710-36723

Guhaniyogi, J., Robinson, V.L. and Stock, A.M. (2006)
Crystal structures of beryllium fluoride-free and beryllium fluoride-bound CheY in complex with the conserved C-terminal peptide of CheZ reveal dual binding modes specific to CheY conformation.
J. Mol. Biol. 359: 624-645

Perez, E., Zheng, H. and Stock, A.M. (2006)
Identification of methylation sites in Thermotoga maritima chemotaxis receptors.
J. Bacteriol. 188: 4093-4100

Toro-Roman A., Wu, T. and Stock, A.M. (2005)
A common dimerization interface in bacterial response regulators KdpE and TorR.
Prot. Sci. 14: 3077-3088

Bachhawat P., Swapna, G.V., Montelione, G.T. and Stock, A.M. (2005)
Mechanism of activation for transcription factor PhoB suggested by different modes of dimerization in the inactive and active states.
Structure 13: 1353-1363

Toro-Roman A., Mack, T.R. and Stock, A.M. (2005)
Structural analysis and solution studies of the activated regulatory domain of the response regulator ArcA: a symmetric dimer mediated by the alpha4-beta5-alpha5 face.
J. Mol. Biol. 349: 11-26

Lubetsky, J.B. and Stock, A.M. (2005)
Two-component signal transduction and chemotaxis..
In: Structural Biology of Bacterial Pathogens,
G. Waksmanm M. Caparon and S. Hultgren, eds.
American Society for Microbiology Press, Washington, D.C. 17-36

Perez, E., West, A.H., Stock, A.M. and Djordjevic S. (2004)
Discrimination between different methylation states of chemotaxis receptor Tar by receptor methyltransferase CheR.
Biochemistry 45: 953-961

Robinson, V.L., Wu, T. and Stock, A.M. (2003)
Structural analysis of the domain interface in DrrB, a response regulator of the OmpR/PhoB subfamily.
J. Bacteriol. 185: 4186-4194

Friedland, N., Liou, H.-L., Lobel, P. and Stock, A.M. (2003)
Structure of a cholesterol-binding protein efficient in Niemann-Pick type C2 disease.
Proc. Natl. Acad. Sci. USA 100: 2512-2517

Robinson, V.L., Hwang, J., Fox, E., Inouye, M. and Stock, A.M. (2002)
Domain arrangement of Der, a switch protein containing two GTPase domains.
Structure 10: 1649- 1658

Stock, A.M. and West, A.H. (2003)
Response regulator proteins and their interactions with histidine protein kinases.
In: Histidine Kinases in Signal Transduction,
M. Inouye and R. Dutta, eds.
Academic Press, New York. 237-271

Anand, G.S. and Stock, A.M. (2002)
The kinetic basis for the stimulatory effect of phosphorylation on the methylesterase activity of CheB.
Biochemistry 41:6752-6760

Bourret, R.B. and Stock, A.M. (2002)
Molecular information processing: lessons from bacterial chemotaxis.
J. Biol. Chem. 277:9625- 9628

Buckler, D.R., Zhou, Y. and Stock, A.M. (2002)
Evidence of intradomain and interdomain flexibility in an OmpR/PhoB homolog from Thermotoga maritima.
Structure 10:153-164

Bourret, R.B., Charon, N.W., Stock, A.M. and West, A.H. (2002)
Bright lights, abundant operons: fluorescence and genomic technologies advance studies of bacterial locomotion and signal transduction: Review of the BLAST meeting, Cuernavaca, Mexico, 14 to 19 January 2001.
J. Bacteriol. 184:1-17

Saxl, R.L., Anand, G.S. and Stock, A.M. (2001)
Synthesis and biochemical characterization of a phosphorylated analog of the response regulator CheB.
Biochemistry 40:12896-12903

Hughes, S.H. and Stock, A.M. (2001)
Techniques in molecular biology and protein expression: Preparing recombinant proteins for X-ray crystallography.
In: International Tables for Crystallography. Vol. F Crystallography of Biological Macromolecules,
M.G. Rossmann and E. Arnold, eds.
Kluwer Academic Publishers, Dordrecht. The Netherlands. 65-80

West, A.H. and Stock, A.M. (2001)
Histidine kinases and response regulator proteins in two-component signaling systems.
Trends Biochem. Sci. 26:369-376

Hughes, C.A., Mandell, J.G., Anand, G.S., Stock, A.M. and Komives, E.A. (2001)
Phosphorylation causes subtle changes in solvent accessibility at the interdomain interface of methylesterase CheB.
J. Mol. Biol. 307:967-976

Robinson, V.L., Buckler, D.R. and Stock, A.M. (2000)
A tale of two components: a novel kinase and a regulatory switch.
Nature Struct. Biol. 7:626-633.

Buckler, D.R. and Stock, A.M. (2000)
Synthesis of [
32P] phosphoramidate for use as a low molecular weight phosphodonor reagent.
Anal. Biochem. 283:222-227.

Anand, G.S., Goudreau, P.N., Lewis, J.K. and Stock, A.M. (2000)
Evidence for phosphorylation- dependent conformational changes in methylesterase CheB.
Protein Sci. 9:898-906.

Buckler, D.R., Anand, G.S. and Stock, A.M. (2000)
Response-regulator phosphorylation and activation: a two-way street? (Commentary)
Trends Microbiol. 8(4):153-155.

Schlichting, I., Berendzen, J., Chu, K., Stock, A.M., Maves, S.A., Benson, D.E., Sweet, R.M., Ringe, D., Petsko, G.A. and Sligar, S.G. (2000)
The catalytic pathway of cytochrome p450cam at atomic resolution.
Science 287(5458):1615-1622.

Stock, A.M., Robinson, V.L. and Goudreau, P.N. (2000)
Two- component signal transduction. (Review)
Annu. Rev. Biochem. 69:183-215.

Stock, A.M. (1999)
A nonlinear stimulus- response relation in bacterial chemotaxis. (Commentary)
Proc. Natl. Acad. Sci. USA 96(20):10945-10947.

Stock, A. (1999)
Relating dynamics to function. (Commentary)
Nature 400(6741):221-222.

Djordjevic, S., Stock, A.M., Chen, Y. and Stock, J.B. (1999)
Protein methyltransferases involved in signal transduction.
In: Structure and Function of AdoMet-Dependent Methyltransferases. X. Cheng and R.M. Blumenthal, eds.
World Scientific Publishing Co./Imperial College Press 149-183.

Robinson, V.L. and Stock, A.M. (1999)
High energy exchange: proteins that make or break phosphoramidate bonds. (Review)
Structure Fold. Des. 7:R47-R53.

Zhang, Z., Komives, E.A., Sugio, S., Blacklow, S.C., Narayana, N., Xuong, N.H., Stock, A.M., Petsko, G.A. and Ringe, D. (1999)
The role of water in the catalytic efficiency of triosephosphate isomerase.
Biochemistry 38(14):4389-4397.

Harrison-McMonagle, P., Denissova, N., Martinez-Hackert, E., Ebright, R.H. and Stock, A.M. (1999)
Orientation of OmpR monomers within an OmpR:DNA complex determined by DNA affinity cleaving.
J. Mol. Biol. 285(2):555-566.

Djordjevic, S. and Stock, A.M. (1998)
Structural analysis of bacterial chemotaxis proteins: components of a dynamic signaling system. (Review)
J. Struct. Biol. 124(2/3):189-200.

Goudreau, P.N., Lee, P.-J. and Stock, A.M. (1998)
Stabilization of the phospho-aspartyl residue involved in a two-component signal transduction pathway in Thermotoga maritima.
Biochemistry 37(41):14575-14584.

Anand, G.S., Goudreau, P.N. and Stock, A.M. (1998)
Activation of methylesterase CheB: Evidence of a dual role for the regulatory domain.
Biochemistry 37(40):14038-14047.

Djordjevic, S. and Stock, A.M. (1998)
Chemotaxis receptor recognition by protein methyltransferase CheR.
Nature Struct. Biol. 5(6):446-450.

Goudreau, P.N. and Stock, A.M. (1998)
Signal transduction in bacteria: molecular mechanisms of stimulus-response coupling. (Review)
Curr. Opin. Microbiol. 1(2):160-169.

Djordjevic, S., Goudreau, P.N., Xu, Q., Stock, A.M. and West, A.H. (1998)
Structural basis for methylesterase CheB regulation by a phosphorylation- activated domain.
Proc. Natl. Acad. Sci. USA 95(4):1381-1386.

Stock, A.M. (1997)
Energy sensors for aerotaxis in Escherichia coli: something old, something new.(Commentary)
Proc. Natl. Acad. Sci. USA 94(20):10487- 10489.

Martinez-Hackert, E. and Stock, A.M. (1997)
Structural relationships in the OmpR family of winged-helix transcription factors. (Review)
J. Mol. Biol. 269(3):301-312.

Djordjevic, S. and Stock, A.M. (1997)
Crystal structure of the chemotaxis receptor methyltransferase CheR suggests a conserved structural motif for binding S-adenosylmethionine.
Structure 5(4):545-558.

Martinez-Hackert, E. and Stock, A.M. (1997)
The DNA-binding domain of OmpR: crystal structure of a winged helix transcription factor.
Structure 5(1):109-124.

Lee, P.J. and Stock, A.M. (1996)
Characterization of the genes and proteins of a two-component system from the hyperthermophilic bacterium
Thermotoga maritima.

J. Bacteriol. 178(19):5579-5585.

Martinez-Hackert, E., Harlocker, S., Inouye, M., Berman, H.M. and Stock, A.M. (1996)
Crystallization, X-ray studies, and site-directed cysteine mutagenesis of the DNA-binding domain of OmpR.
Protein Sci. 5(7):1429-1433.

Stock, A.M. and Mowbray, S.L. (1995)
Bacterial chemotaxis: a field in motion. (Review)
Curr. Opin. Struct. Biol. 5(6):744- 751.

West, A.H., Martinez-Hackert, E. and Stock, A.M. (1995)
Crystal structure of the catalytic domain of the chemotaxis receptor methylesterase, CheB.
J. Mol. Biol. 250(2):276-290.

West, A.H., Djordjevic, S., Martinez-Hackert, E. and Stock, A.M. (1995)
Purification, crystallization, and preliminary X-ray diffraction analyses of the bacterial chemotaxis receptor modifying enzymes.
Proteins 21(4):345-350.

West, A.H., Martinez-Hackert, E. and Stock, A.M. (1994)
Structural basis for the mechanism of phosphoryl transfer in bacterial chemotaxis.
In: Molecular Biology of Phosphate in Microorganisms, A.M. Torriani, S. Silver and E. Yagil, eds.
American Society for Microbiology, Washington, D.C. 309-314.

Stock, A.M. and Shinagawa, H. (1994)
Signal transduction and phosphoproteins.
In: Molecular Biology of Phosphate in Microorganisms, A.M. Torriani, S. Silver and E. Yagil, eds.
American Society for Microbiology, Washington, D.C. 282-284.

Stock, A.M., Martinez-Hackert, E., Rasmussen, B.F., West, A., Stock, J.B., Ringe, D. and Petsko, G.A. (1993)
Structure of the Mg
2+- bound form of CheY and mechanism of phosphoryl transfer in bacterial chemotaxis.
Biochemistry 32(49):13375- 13380.

DeKoster, G.T., Robertson, A.D., Stock, A.M. and Stock, J.B. (1993)
Urea and guanidine-HCl yield different unfolding free energies for CheY: Which denaturant provides the most reliable free energy values?
Techniques in Protein Chem. 4:533-540.

Singer, P.T., Carty, R.P., Berman, L.E., Schlichting, I., Stock, A., Smalas, A., Cai, Z.,
Mangel, W.F., Jones, K.W. and Sweet, R.M. (1992)
Laue diffraction as a tool in dynamic studies: hydrolysis of a transiently stable intermediate in catalysis by trypsin.
Phil. Trans. R. Soc. Lond. A340:285-300.

Stock, J.B., Surette, M., McCleary, W. and Stock, A. (1992)
Signal transduction in bacterial chemotaxis. (Review)
J. Biol. Chem. 267(28):19753-19756.

Rasmussen, B.F., Stock, A.M., Ringe, D. and Petsko, G.A. (1992)
Crystalline ribonuclease A loses function below the dynamical transition at 220 K.
Nature 357(6377):423-424.

Lukat, G.S., McCleary, W.R., Stock, A.M. and Stock, J.B. (1992)
Phosphorylation of bacterial response regulator proteins by low molecular weight phospho- donors.
Proc. Natl. Acad. Sci. USA 89(2):718-722.

Lukat, G.S., Lee, B., Mottonen, J.M., Stock, A.M. and Stock, J.B. (1991)
Roles of the highly conserved aspartate and lysine residues in the response regulator of bacterial chemotaxis.
J. Biol. Chem. 266(13):8348-8354.

Stock, J.B., Lukat, G.S. and Stock, A.M. (1991)
Bacterial chemotaxis and the molecular logic of intracellular signal transduction networks. (Review)
Annu. Rev. Biophys. Biophys. Chem. 20:109-136.

Ninfa, E.G., Stock, A., Mowbray, S. and Stock, J. (1991)
Reconstitution of the bacterial chemotaxis signal transduction system from purified components.
J. Biol. Chem. 266:9764-9770.


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